Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway

CONCLUSION: LBH589 combined with AM1241 activated the endoplasmic reticulum emergency pathway, DNA damage repair signaling pathway, oxidative stress and autophagy pathway, ultimately promoting the apoptosis of cervical cancer cells. These findings suggest that the co-administration of LBH589 and AM1241 may be a new treatment plan for the treatment of cervical cancer.PMID:37740231 | PMC:PMC10517494 | DOI:10.1186/s40360-023-00686-7
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Source Type: research