Early chemotherapeutic intervention to avoid thyroidectomy in pediatric Langerhans cell histiocytosis with thyroid involvement accompanying tracheal stenosis: a report of two cases

In this report, we describe the cases of two children who presented with tracheal stenosis caused by thyroid LCH, both of which were successfully treated by early induction of chemotherapy, and one of which was also treated for a shorter duration. Mutation analysis detected in-frame deletions of BRAF exon 12 in both cases. These cases suggest that timely diagnosis and administration of chemotherapy may alleviate severe airway obstruction and reduce the need for thyroidectomy in pediatric patients with thyroid LCH.PMID:37740816 | DOI:10.1007/s12185-023-03662-3

Source: International Journal of Hematology - September 23, 2023 Category: Hematology Authors: Shuhei Aoyama Kohei Fukuoka Hirohito Kubota Kotaro Narita Ko Kudo Yuichi Mitani Koichi Oshima Makiko Mori Yuki Arakawa Kayoko Ichimura Kiminori Terui Yutaka Tanami Hiroshi Kawashima Atsuko Nakazawa Takehiro Niitsu Yoshiyuki Takahashi Katsuyoshi Koh Source Type: research