Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine

This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-OHDA-induced apoptosis. Thus, we suggest that the BSEE can be explored as a possible cytoprotective agent for Parkinson's disease due to its high antioxidant capacity and anti-apoptotic action.PMID:37725292 | DOI:10.1007/s11064-023-04028-1

Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research