Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

ConclusionsWe report a case of CCSCC of the oral cavity withPIK3CA andHRAS mutations. The identification ofPIK3CA and/orHRAS mutations is rare in SCC; however, both mutations are important potential targets for antitumor therapy. A detailed analysis of gene mutations in CCSCC may lead to a better understanding of its biological behavior and an improved prognosis, as well as a differential diagnosis from other clear cell neoplasms.
Source: Head and Neck Pathology - Category: Pathology Source Type: research