Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice

CONCLUSIONS: Overall, our results characterize a new versatile neurotoxic animal model of ALS that may be useful for the identification of new druggable targets to develop innovative therapeutic strategies for this disease.PMID:37729728 | DOI:10.1016/j.biopha.2023.115503

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Serenella Anzilotti Valeria Valente Paola Brancaccio Cristina Franco Antonella Casamassa Giovanna Lombardi Alessandra Palazzi Andrea Conte Simona Paladino Lorella Maria Teresa Canzoniero Lucio Annunziato Giovanna Maria Pierantoni Giuseppe Pignataro Source Type: research