Glaucoma Following Cataract Surgery in Children —Finally, a Clue

Childhood cataract is among the more common treatable causes of childhood visual disability and blindness, representing some 10% to 15% of children enrolled globally in schools for blind individuals. Congenital cataracts are genetically heterogeneous with 234 entries on Online Mendelian Inheritance in Man using the search terms congenital cataract. They may be isolated, associated with other ocular anomalies such as microphthalmia or sclerocornea, or be a part of systemic disorders such as trisomy 21 or Lowe syndrome. Some are associated with metabolic conditions such as galactosemia or cerebrotendinous xanthomatosis that can be treated with dietary modifications or targeted medications. Congenital cataracts and congenital glaucoma may coexist in certain systemic conditions such as POMGNT1-associated dystroglycanopathy or Stickler syndrome but are not specifically associated with glaucoma following cataract surgery (GFCS). Genes causing isolated congenital glaucoma such as CYP1B1 or LTBP2 or those associated with anterior segment dysgenesis have not been reported to cause GFCS.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research