Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer

In this report, we show TH ± E2 ± tamoxifen inhibits cell cycle control signaling, reduces apoptosis, and enhances cell proliferation, tumor growth, tamoxifen resistance, and clonal expansion. Mechanistically these changes involve numerous genes and pathways, including critical cell cycle regulatory proteins and genes identified using various molecular methods. These studies facilitate a greater mechanistic understanding of the biological and molecular impact of TH on SR+ BC.PMID:37723865 | DOI:10.1080/15384101.2023.2249702

Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Reema S Wahdan-Alaswad Susan M Edgerton Hyun Min Kim Aik Choon Tan Bryan R Haugen Bolin Liu Ann D Thor Source Type: research