Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer

CONCLUSIONS: Our study provides evidence that IDO1 expression serves as a positive prognostic marker in HGSOC and is associated with an increased number of CD3+, CD4+ and CD8+ TILs. Understanding the intricate relationship between IDO1, TILs, and the tumor microenvironment may hold the key to improving outcomes in HGSOC.PMID:37703626 | PMC:PMC10502412 | DOI:10.1016/j.neo.2023.100934

Source: Neoplasia - September 13, 2023 Category: Cancer & Oncology Authors: Inga Hoffmann Mihnea P Dragomir Nanna Monj é Carlotta Keunecke Catarina Alisa Kunze Simon Schallenberg Sofya Marchenko Wolfgang D Schmitt Hagen Kulbe Jalid Sehouli Ioana Elena Braicu Paul Jank Carsten Denkert Silvia Darb-Esfahani David Horst Bruno V Sinn Source Type: research