Pharmacokinetic evaluation of 24 representative components of Ling-Gui-Zhu-Gan decoction in acute myocardial infarction model rats via a validated ultrahigh-performance liquid chromatography-tandem mass spectrometry method

CONCLUSIONS: The specificity, linearity, precision and accuracy, recovery, matrix effect and stability were validated according to Food and Drug Administration guidance. The validation results demonstrated that the method could be applied to evaluate the pharmacokinetic parameters of LGZGD in AMI rats. The pharmacokinetic parameters showed substantial improvement in quality research of LGZGD, thereby laying the groundwork for preclinical and clinical trials in chronic heart failure clinical efficacy.PMID:37698150 | DOI:10.1002/rcm.9620

Source: Rapid Communications in Mass Spectrometry : RCM - September 12, 2023 Category: Chemistry Authors: Jing Li Ruirui Ge Feng Wang Jinfan Gu Mengyu Zuo Tongjuan Tang Xinru Ge Yingchao Niu Liang Wang Jinling Huang Jian Chen Source Type: research