An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria

ConclusionsA within-host pharmacometric model is proposed in which it is hypothesized that some malaria parasites enter a temporary drug refractory state after exposure to artemisinin antimalarials, which is followed by delayed parasite death or reactivation. The model fitted the observed sequential parasite density data from patients with acuteP. falciparum malaria, and it supported reduced ring stage activity in artemisinin-resistant infections.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research