Cefepime in vivo activity against carbapenem-resistant Enterobacterales that test as cefepime susceptible or susceptible-dose dependent in vitro: implications for clinical microbiology laboratory and clinicians

ConclusionsData indicate to avoid cefepime for the treatment of serious infections caused by CRE isolates that test as cefepime susceptible or SDD. Data also provide evidence that isolates with the same antibiotic MIC may have different pharmacokinetic/pharmacodynamic profiles due to their antimicrobial resistance mechanism.

https://academic.oup.com/jac/article/78/9/2242/7233845?rss=1

Source: Journal of Antimicrobial Chemotherapy - July 31, 2023 Category: Microbiology Source Type: research