Investigation of VEGF (rs 699947) polymorphism in the progression of Rheumatoid Arthritis (RA) and in-silico nanoparticle drug delivery of potential phytochemicals to cure RA

In this study, it had been shown that allele A frequency was significantly higher than that of allele C in RA-positive patients as compared to controls. Hence it depicts that allele A of VEGF (rs699947) can increase the risk of RA while allele C has a protective role. The phytochemicals which showed maximum binding affinity at the inhibitory site of BTK include beta boswellic acid, tanshinone, and baicalin. These phytochemicals as BTK inhibitor give insights to use them as anti-arthritic compounds by nanoparticle drug delivery mechanism.PMID:37669474 | DOI:10.18388/abp.2020_6654

Source: Acta Biochim Pol - September 5, 2023 Category: Biochemistry Authors: Nageen Hussain Mohsin Mumtaz Mohammad Adil Abad Ali Nadeem Abid Sarwar Tariq Aziz Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Mousa Essa Alharbi Source Type: research