Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity

CONCLUSIONS: Platelet oxygen consumption as a measure of mitochondrial function may be useful as a biomarker of hepatic APAP toxicity in the setting of moderate to severe overdose. Treatment with 4-MP decreases hepatic necrosis and may mitigate the harmful effects of APAP on platelet mitochondrial function detected via POC.PMID:37644341 | DOI:10.1007/s13181-023-00964-0

Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Carolyn Fox Michael L Ekaney Michael Runyon Hieu M Nguyen Philip J Turk Iain H McKillop Christine M Murphy Source Type: research