Anti-HIV Drugs Lopinavir/Ritonavir Activate Bitter Taste Receptors

In this study, we utilized a calcium mobilization assay to characterize the activation of bitter taste receptors by lopinavir and ritonavir. We discovered that lopinavir activates TAS2R1 and TAS2R13, while ritonavir activates TAS2R1, TAS2R8, TAS2R13, and TAS2R14. The development of bitter taste blockers that target these receptors with a safe profile would be highly desirable in eliminating the unpleasant bitter taste of these anti-HIV drugs.PMID:37625013 | DOI:10.1093/chemse/bjad035

Source: Chemical Senses - August 25, 2023 Category: Biochemistry Authors: Shurui Chen Xinyi Zhou Yongcheng Lu Keman Xu Jiao Wen Meng Cui Source Type: research