Distributed Genetic Effects of the Corpus Callosum Subregions Suggest Links to Neuropsychiatric Disorders and Related Traits

CONCLUSIONS: Our results demonstrate that the CC has a polygenic architecture implicating multiple genes, and show that CC subregion volumes are heritable. We found distinct genetic factors are involved in the development of anterior and posterior subregions, consistent with their divergent functional specialization. Significant genetic correlation between volumes of the CC and bipolar disorder, drinks per week, major depressive disorder and cannabis consumption subregion volumes with psychiatric traits is noteworthy and deserving of further investigation.PMID:37612147 | DOI:10.1017/neu.2023.32

Source: Acta Neuropsychiatrica - August 23, 2023 Category: Psychiatry Authors: Megan L Campbell Shareefa Dalvie Alexey Shadrin Dennis van der Meer Kevin O'Connell Oleksander Frei Ole A Andreassen Dan J Stein Jaroslav Rokicki Source Type: research