The effect of genetic variation in estrogen transportation and metabolism on the severity of menopause symptoms: A study from the RIGHT 10K cohort

Hot flashes and night sweats (vasomotor symptoms, VMS) are the most common symptom of the menopause transition, affecting up to three-fourths of women in this phase of life [1]. They are severe in intensity in about one-third of affected women, and can significantly impact mood, sleep, sexual function and quality of life [2 –5]. In addition to these more immediate consequences of VMS, there is increasing recognition that VMS are predictive of disease risk in women, including risk of cardiovascular disease [1,6], low bone density and fractures [7,8], and breast cancer [9].

Source: Maturitas - August 16, 2023 Category: Primary Care Authors: Ekta Kapoor, Stephanie S. Faubion, Carol L. Kuhle, Juliana M. Kling, Virginia M. Miller, Shawn Fokken, Kristin C. Mara, Ann M. Moyer Tags: Original article Source Type: research