Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination

Intern Med. 2023;62(16):2381-2387. doi: 10.2169/internalmedicine.1631-23. Epub 2023 Aug 15.ABSTRACTWe herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.PMID:37587055 | DOI:10.2169/internalmedicine.1631-23

Source: Internal Medicine - August 16, 2023 Category: Internal Medicine Authors: Erika Hishida Yuko Ono Kazuho Oe Toshimi Imai Hiromichi Yoshizawa Takeo Nakaya Hirotoshi Kawata Tetsu Akimoto Osamu Saito Daisuke Nagata Source Type: research