Neurophysiological Biomarkers as a Springboard for the Refinement of Transcranial Magnetic Stimulation Therapy: Stratification, Mechanisms of Action, and Next Steps

In the current issue of Biological Psychiatry, Strafella et  al. (1) take an important step forward in the study of transcranial magnetic stimulation (TMS) therapy for major depressive disorder (MDD). The authors evaluate TMS–electroencephalography (TMS-EEG)-evoked potential components as putative biomarkers of intermittent theta burst stimulation (iTBS) clinical outcome within the context of a larger triple-blind randomized controlled clinical trial. The highest-powered study of its kind to date (N = 114 patients), this study carefully examines the interaction between clinical predictors (baseline) and clinical targets (posttreatment changes).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research