PPAR δ activation improves cardiac mitochondrial homeostasis in desmin deficient mice but does not alleviate systolic dysfunction

In this study, we sought to investigate whether pharmacological activation of PPARδ via intraperitoneal administration of the se lective ligand GW0742 could ameliorate heart failure and mitochondrial dysfunction that have been previously reported in a characterized genetic model of heart failure, the desmin null mice (Des−/−).

Source: Journal of Molecular and Cellular Cardiology - August 20, 2023 Category: Cytology Authors: Dimitra Palioura, Kyriakos Mellidis, Konstantina Ioannidou-Kabouri, Eleftheria Galatou, Eleni-Taxiarchia Mouchtouri, Rodopi Stamatiou, Panagiotis Mavrommatis-Parasidis, Emmanuel Panteris, Aimilia Varela, Constantinos Davos, Konstantinos Drosatos, Manolis Source Type: research