Acute tubular injury in a patient with acetaminophen toxicity

A 31-year-old woman with a history of alcohol abuse presented with nonoliguric acute kidney injury, mild pancreatitis, and diarrhea. Her only medication was acetaminophen, 1 to 2 g every 4 to 6 hours for 4 days for abdominal pain. Admission blood pressure was 122/74 mm  Hg with serum creatinine of 9.16 mg/dl (baseline, 0.5 mg/dl), requiring dialysis. Urine sediment was inactive. Blood ethanol was undetectable. Aspartate and alanine transaminases were>20,000 U/L and 3799 U/L, respectively. Creatine kinase level was normal.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research