PYK2, a hub of signaling networks in breast cancer progression

We describe unique roles of the non-receptor tyrosine kinase (NRTK) PYK2 in signaling integration and feedback looping in BC. PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling dynamics, and contributes to BC growth, epithelial-to-mesenchymal transition (EMT), stemness, migration, invasion, and metastasis. We also discuss the potential of PYK2 as a therapeutic target in various BC subtypes.PMID:37586982 | DOI:10.1016/j.tcb.2023.07.006
Source: Trends in Cell Biology - Category: Cytology Authors: Source Type: research