Some pleiotropic effects of statins on hepatocellular carcinoma cells: Comparative study on atorvastatin, rosuvastatin and simvastatin

CONCLUSION: The less pronounced pleiotropic effects of rosuvastatin on HepG2 cells are probably due to differences in structure and solubility compared to atorvastatin and simvastatin. Transporter-dependent and a slower influx of rosuvastatin into cells compared to the tested lipophilic statins probably lead to a weaker accumulation of rosuvastatin in HepG2 cells, which results in less pronounced pleiotropic effects compared to lipophilic atorvastatin and simvastatin.PMID:37478516 | DOI:10.1016/j.advms.2023.07.002

Source: Advances in Medical Sciences - July 21, 2023 Category: Biomedical Science Authors: Esmeralda Dautovi ć Monika Rustemovi ć-Čorbić Nahida Srabovi ć Adaleta Softi ć Aida Smajlovi ć Maida Šljivić Husejnović Alen Hatki ć Dalila Halil čević Source Type: research