Is Methotrexate Ototoxic? Investigating the Ototoxic Late Effects of Pediatric Cancer Treatment

CONCLUSIONS: The results from this study suggest that children who receive therapies not clinically established as ototoxic (i.e., methotrexate) may still be at a high risk of developing long-term hearing loss as a late effect. Due to the high incidence rate of hearing loss among patients with pediatric cancer, we recommend that audiologists be part of the late-effects care team. This study also demonstrates that patients with pediatric cancer treated with methotrexate should receive routine long-term auditory monitoring as part of their standard of care to detect and manage hearing loss early, minimizing adverse outcomes.PMID:37532243 | DOI:10.1044/2023_AJA-22-00157

Source: American Journal of Audiology - August 2, 2023 Category: Audiology Authors: Brittney Moore Gabrielle Sheets Jordan Doss Ayesha Umrigar Michael Norman Zhide Fang Pinki Prasad Amanda Musso Sloane Clay Fern Tsien Source Type: research