Eosinophilic granulomatosis with polyangiitis presenting as aspirin –exacerbated respiratory disease

Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystem disorder causing granulomatous inflammation of both small- and medium-sized arteries with hypereosinophilia and eosinophilic systemic tissue infiltration. EGPA can involve the lungs, sinuses, kidneys, heart, nervous system, intestinal tract, or skin.1 Onset is usually between the third and fifth decades of life with the following 3 stages: the prodromal stage with atopic diseases, that is, allergic rhinitis and asthma; the eosinophilic stage where organs become infiltrated with eosinophils and peripheral blood hypereosinophilia; and the final vasculitic stage where granulomatous vascular inflammation occurs.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research