Rationale and design of an investigator-initiated, multicenter, prospective, placebo-controlled, double-blind, randomized trial to evaluate the effects of finerenone on vascular stiffness and cardiorenal biomarkers in type 2 diabetes and chronic kidney disease (FIVE-STAR)

The overactivation of mineralocorticoid receptor (MR) plays a key pathological role in the progression of cardiovascular and renal diseases by promoting pro-inflammatory and pro-fibrotic signaling. Recently, i...

Source: Cardiovascular Diabetology - July 31, 2023 Category: Cardiology Authors: Atsushi Tanaka, Hirotaka Shibata, Takumi Imai, Hisako Yoshida, Motoaki Miyazono, Naohiko Takahashi, Daiju Fukuda, Yosuke Okada, Hiroki Teragawa, Satoru Suwa, Keisuke Kida, Masao Moroi, Isao Taguchi, Shigeru Toyoda, Michio Shimabukuro, Kengo Tanabe & helli Tags: Study Protocol Source Type: research