Non-adaptive evolution in codon usage of human-origin monkeypox virus

This study also found that the mutations of Mpox led to changes in non-adaptative genes in different organs. Additionally, we found that codon usage of Mpox was less similar to that of up-regulated host genes and more similar to that of down-regulated host genes post-infection, indicating that codon usage affects host gene expression. Overall, the study highlights the non-adaptive changes in codon usage as a potential cause of differences in Mpox virulence and provides insights into the evolutionary and adaptive mechanisms of Mpox and its potential impact on pathogenicity and host adaptation.PMID:37487313 | DOI:10.1016/j.cimid.2023.102024
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Source Type: research