Nodular Regenerative Hyperplasia

AbstractNodular regenerative hyperplasia (NRH) is a diffuse liver disease characterized by multiple hepatic nodules in the absence of significant fibrosis.Purpose of ReviewTo discuss the etiopathogenesis, imaging features, pathological diagnosis, clinical features, and management of NRH.Recent FindingsNRH may occur in patients with various predisposing systemic conditions, and also post liver transplant. Not all patients are symptomatic, and portal hypertension occurs only in a subset of cases. Imaging features often show overlap with cirrhosis. Transient elastography and magnetic resonance elastography may have a role in differentiation. The term “porto-sinusoidal vascular disease” (PSVD) has been defined as a clinical entity, which includes all patients with the absence of cirrhosis and characteristic histological findings, with or without portal hypertension. NRH is one of the specific histological lesions in the defining criteria for PSVD.SummaryManagement of portal hypertension in NRH is similar to patients with cirrhosis, but overall prognosis is better.
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research