Diet-Derived and Diet-Related Endogenously Produced Palmitic Acid: Effects on Metabolic Regulation and Cardiovascular Disease Risk

The relationships between intake and tissue levels of saturated fatty acids (SFAs) and cardiovascular disease (CVD) risk have been extensively studied over the past six decades. Individual SFAs differ in their metabolic effects. Palmitic acid (C16:0), a long chain fatty acid (FA), is the most abundant SFA in the U.S. diet representing about 55% of dietary SFAs1, and comprises about 20-30% of all FA in membrane phospholipids (PL) and triglycerides (TG)2. Palmitic acid is derived from the diet or by endogenous synthesis (i.e., de novo lipogenesis (DNL)) from excess energy intake from carbohydrates and/or protein.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Review Article Source Type: research