Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases

CONCLUSION: This study has confirmed using big data, that EPZ, the optical isomer and racemic form of omeprazole, has the beneficial characteristics of being less sensitive to CYP, as was intended by its design.PMID:37482254 | DOI:10.1016/j.taap.2023.116632

Source: Toxicology and Applied Pharmacology - July 23, 2023 Category: Toxicology Authors: Mami Neishi Hirofumi Hamano Takahiro Niimura Masaya Denda Kenta Yagi Koji Miyata Tsung-Jen Lin Tsukasa Higashionna Mitsuhiro Goda Yoshito Zamami Keisuke Ishizawa Hideki Nawa Source Type: research