Serum microRNA ‐501‐3p is a potential diagnostic tool for detecting mild cognitive impairment: Ehime genome study

Blood –brain barrier (BBB) disruption is associated with cognitive decline, and miR-501-3p negatively regulates cerebral endothelial tight junction protein-1, leading to BBB disruption. The study aimed to investigate whether serum exosome miR-501-3p levels could serve as a clinical indicator for detecti ng mild cognitive impairment (MCI). The results showed that elevated expression of blood exosomal miR-501-3p is associated with the presence of MCI in human patients. Early detection of vascular injuries may reduce progressive dementia through the management of vascular risk factors. AbstractTight junction disruption and dysfunction are involved in the progression of blood –brain barrier (BBB) breakdown. Recent investigations have revealed BBB disruption in patients with vascular cognitive decline. Our previous studies showed that miR-501-3p negatively regulates cerebral endothelial tight junction protein-1, resulting in the disruption of the BBB, and playing an imp ortant role in the development of vascular cognitive impairment. BBB breakdown in white matter lesions is often seen in the patients with vascular mild cognitive impairment (MCI). We therefore hypothesize that most early-phase MCI patients may demonstrate elevated expression of miR-501-3p and sought to investigate whether serum exosome miR-501-3p levels could be a clinical indicator for detecting mild cognitive impairment. One hundred and seventy-eight subjects (aged 73 [68–75] years, 53% male) were recruited...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research