Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

ConclusionThrough a relatively simple ligand-based similarity search, we identified a new radioligand that binds with high affinity (<10 nM) to α-synuclein fibrils and PD tissue. Although the radioligand has suboptimal selectivity for α-synuclein towards Aβ and high non-specific binding, we show here that a simplein silico approach is a promising strategy to identify novel ligands for target proteins in the CNS with the potential to be radiolabeled for PET neuroimaging studies.

Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research