RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure

We read with great interest the article recently published (June 05, 2023) by Schmeckpeper et al. in the Journal of Molecular and Cellular Cardiology, supporting the notion that RyR2 stabilization with dantrolene prevents lethal ventricular tachycardia (VT) and pathological left ventricular (LV) remodeling and improves cardiac function in a mouse model of post-myocardial infarction (MI) [1]. We agree with all observations that have been made to show the acute and chronic effects of dantrolene in a chronic ischemic heart disease model.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research