Oxidative Stress-induced liver damage and remodeling of the liver vasculature

As an organ critically important for targeting and clearing viruses, bacteria, and other foreign material, the liver operates via immune-tolerant, anti-inflammatory mechanisms indispensable to the immune response. Stress and stress-induced factors disrupt the homeostatic balance in the liver, inflicting tissue damage, injury, and remodeling. These factors include oxidative stress induced by viral infections, environmental toxins, drugs, alcohol, and diet. A recurrent theme seen amongst stressors common to multiple liver disease is the induction of mitochondrial dysfunction, increased ROS expression and depletion of ATP.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research