Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report

We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta.

Source: Neurology Neuroimmunology and Neuroinflammation - June 20, 2023 Category: Neurology Authors: Rolfes, M., Harroud, A., Zorn, K. C., Tubati, A., Omura, C., Kurtz, K., Matloubian, M., Berger, A., Chiu, C. Y., Wilson, M. R., Ramachandran, P. S. Tags: All Immunology, Encephalitis, Meningitis Diagnostic [amp ] Treatment Challenges Source Type: research