Glucocorticoid-induced activation of NOX/ROS/NF- κB signaling in MSCs contributes to the development of GONFH
Conclusion: We demonstrated for the first time that the aggravation of the OS microenvironment in MSCs caused by high doses of GCs leading to apoptosis and differentiation imbalance is a crucial factor in the pathogenesis of GONFH, mediated through activating the NOX/ROS/NF- κB signaling pathway.
Source: Apoptosis - Category: Molecular Biology Source Type: research
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