Glucocorticoid-induced activation of NOX/ROS/NF- κB signaling in MSCs contributes to the development of GONFH

Conclusion: We demonstrated for the first time that the aggravation of the OS microenvironment in MSCs caused by high doses of GCs leading to apoptosis and differentiation imbalance is a crucial factor in the pathogenesis of GONFH, mediated through activating the NOX/ROS/NF- κB signaling pathway.
Source: Apoptosis - Category: Molecular Biology Source Type: research