Viruses, Vol. 15, Pages 1290: Does Intra-Uterine Exposure to the Zika Virus Increase Risks of Cognitive Delay at Preschool Ages? Findings from a Zika-Exposed Cohort from Grenada, West Indies
Viruses, Vol. 15, Pages 1290: Does Intra-Uterine Exposure to the Zika Virus Increase Risks of Cognitive Delay at Preschool Ages? Findings from a Zika-Exposed Cohort from Grenada, West Indies
Viruses doi: 10.3390/v15061290
Authors:
Michelle Fernandes
Roberta Evans
Mira Cheng
Barbara Landon
Trevor Noël
Calum Macpherson
Nikita Cudjoe
Kemi S. Burgen
Randall Waechter
A. Desiree LaBeaud
Karen Blackmon
Maternal infection with Zika virus (ZIKV) is associated with a distinct pattern of birth defects, known as congenital Zika syndrome (CZS). In ZIKV-exposed children without CZS, it is often unclear whether they were protected from in utero infection and neurotropism. Early neurodevelopmental assessment is essential for detecting neurodevelopmental delays (NDDs) and prioritizing at-risk children for early intervention. We compared neurodevelopmental outcomes between ZIKV-exposed and unexposed children at 1, 3 and 4 years to assess exposure-associated NDD risk. A total of 384 mother–child dyads were enrolled during a period of active ZIKV transmission (2016–2017) in Grenada, West Indies. Exposure status was based on laboratory assessment of prenatal and postnatal maternal serum. Neurodevelopment was assessed using the Oxford Neurodevelopment Assessment, the NEPSY® Second Edition and Cardiff Vision Tests, at 12 (n = 66), 36 (n = 58) and 48 (n = 59) months, respectively. There were no differences in NDD rates or vision sc...
Source: Viruses - Category: Virology Authors: Michelle Fernandes Roberta Evans Mira Cheng Barbara Landon Trevor No ël Calum Macpherson Nikita Cudjoe Kemi S. Burgen Randall Waechter A. Desiree LaBeaud Karen Blackmon Tags: Article Source Type: research
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