An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease

Sickle cell disease (SCD) is a common monogenic disorder that affects over 100,000 people in the United States alone, and millions more worldwide [1]. The disease is generally characterized by red blood cell sickling, episodic vaso-occlusive crises (VOC), and other symptoms associated with pain and inflammation [2]. SCD is an inherited pathology influenced by a point mutation of the β-globin gene that results in an abnormal type of hemoglobin, the S variant (HbS) [3]. While the classical paradigm of SCD considers the sickling and polymerization of HbS as the primary cause of its physiological complications, more recent advancements suggest a multifactorial etiology that includ es hemolysis, oxidative stress, and chronic inflammation as additional factors that should be considered [4,5].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 7, 2023 Category: Biomedical Science Authors: K.V. Giriraja, S.K. Bhatnagar, L. Tomlinson, F. Sancilio Tags: Short communication Source Type: research