TAMs PD-L1(+) in the reprogramming of germ cell tumors of the testis

CONCLUSIONS: TAMs PD-L1(+) levels gradually decrease during the reprogramming of S cells {P-S [(high values of TAMs PD-L1(+)] → S-C and EC [(intermediate values of TAMs PD-L1(+)] → other NS-GCTT [(low values of TAMs PD-L1(+)], supporting a complex pathogenetic model where the interactions between tumor cells and TME components [and specifically TAMs PD-L1(+)] play a key role in determining the fate of GCTT.PMID:37209574 | DOI:10.1016/j.prp.2023.154540

Source: Cell Research - May 20, 2023 Category: Cytology Authors: Sofia Melotti Francesca Ambrosi Tania Franceschini Francesca Giunchi Giorgia Di Filippo Eugenia Franchini Francesco Massari Veronica Mollica Valentina Tateo Federico Mineo Bianchi Maurizio Colecchia Andres Martin Acosta Jo ão Lobo Michelangelo Fiorentino Source Type: research