Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na + /K + -ATPase Impairment in the Rat Brain

ConclusionsThe results demonstrate cortical ion homeostasis perturbation and specific Na+/K+-ATPase impairment during deep isoflurane anesthesia. Slowed potassium clearance and extracellular accumulation might modulate cortical excitability during burst suppression generation, while prolonged Na+/K+-ATPase impairment could contribute to neuronal dysfunction after deep anesthesia.Editor ’s PerspectiveWhat We Already Know about This TopicChanges in extracellular ion composition modulate neuronal network activityThe sodium/potassium-adenosine triphosphatase (Na+/K+-ATPase) enzyme plays an essential role in the maintenance of physiologic ion distributionsThe effects of general anesthetics on ion homeostasis and on Na+/K+-ATPase enzyme activity are incompletely exploredWhat This Article Tells Us That Is NewIn vitro exposure of rat cortical slices to isoflurane led to a decreased activity of Na+/K+-ATPase and to a concomitant increase in extracellular potassium concentrationsIsoflurane-induced burst suppression in adult rats resulted in slowed extracellular potassium clearance and extracellular potassium accumulationin vivoThese laboratory observations suggest that deep isoflurane anesthesiavia the modulation of Na+/K+-ATPase activity may induce perturbations of ion homeostasis in the central nervous system
Source: Anesthesiology - Category: Anesthesiology Source Type: research