[99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression

ConclusionThis study is the first to report PD-L1 expression of the heart that can be quantified non-invasively without invasive myocardial biopsy, with high reliability and specificity. This technique can be applied to investigate myocardial PD-L1 expression in ICI-associated myocarditis and cardiomyopathies.Clinical trial registration PD-L1 Expression in Cancer (PECan) study (NCT04436406).https://clinicaltrials.gov/ct2/show/NCT04436406 June 18th, 2020.
Source: EJNMMI Research - Category: Radiology Source Type: research