Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis

ConclusionsThe present results suggest shared molecular mechanisms for glomerular injury in IgAN and IgAVN, except for enhanced glomerular complement activation in IgAN. Differences in the protein abundance of podocyte-associated and GBM proteins between IgAN and IgAVN patients with and without NS may be associated with the severity of proteinuria.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research