Is hypertriglyceridemia a reliable indicator of cholesterol-depleted apoB particles?
In 2019, based on evidence from prospective observational studies, mendelian randomization analyses, and randomized clinical trials, the European Society of Cardiology/European Atherosclerosis (ESC/EAS) guidelines concluded that apoB is a more accurate measure of the cardiovascular risk due to the apoB lipoprotein particles than LDL cholesterol (LDL-C) or non-high density lipoprotein cholesterol (non-HDL-C).1 Since then, the evidence has grown even stronger with additional mendelian randomization studies demonstrating that apoB includes the cardiovascular risk attributable to triglycerides, LDL-C and even HDL-C and identifies increased cardiovascular risk as well as decreased longevity in first degree relatives of those with an elevated apoB.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Davide De Marco, Karol Pencina, Michael Pencina, Line Dufresne, George Thanassoulis, Allan D. Sniderman Tags: Original Research Source Type: research
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