Viruses, Vol. 15, Pages 1148: Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs
Viruses, Vol. 15, Pages 1148: Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs
Viruses doi: 10.3390/v15051148
Authors:
Sita Awasthi
Motoyasu Onishi
John M. Lubinski
Bernard T. Fowler
Alexis M. Naughton
Lauren M. Hook
Kevin P. Egan
Masaki Hagiwara
Seiki Shirai
Akiho Sakai
Takayuki Nakagawa
Kumiko Goto
Osamu Yoshida
Alisa J. Stephens
Grace Choi
Gary H. Cohen
Kazufumi Katayama
Harvey M. Friedman
Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent recurrent genital lesions and concerns about transmitting infection to intimate partners affect the quality of life of infected individuals. Therapeutic vaccines are urgently needed to reduce the frequency of genital lesions and transmission. S-540956 is a novel vaccine adjuvant that contains CpG oligonucleotide ODN2006 annealed to its complementary sequence and conjugated to a lipid that targets the adjuvant to lymph nodes. Our primary goal was to compare S-540956 administered with HSV-2 glycoprotein D (gD2) with no treatment in a guinea pig model of recurrent genital herpes (studies 1 and 2). Our secondary goals were to compare S-540956 with oligonucleotide ODN2006 (study1) or glucopyranosyl lipid A in a stable oil-in-water nano-emulsion (GLA-SE) (stu...
Source: Viruses - Category: Virology Authors: Sita Awasthi Motoyasu Onishi John M. Lubinski Bernard T. Fowler Alexis M. Naughton Lauren M. Hook Kevin P. Egan Masaki Hagiwara Seiki Shirai Akiho Sakai Takayuki Nakagawa Kumiko Goto Osamu Yoshida Alisa J. Stephens Grace Choi Gary H. Cohen Kazufumi Kataya Tags: Article Source Type: research
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