RNA sequencing identifies novel NRG1-fusions in solid tumors that lack co-occurring oncogenic drivers

NRG1 gene fusions are rare, therapeutically relevant, oncogenic drivers that occur across solid tumor types. To understand the landscape of NRG1 gene fusions, 4,397 solid tumor FFPE samples consecutively tested by comprehensive genomic and immune profiling during standard care were analyzed. Nineteen (19) NRG1 fusions were found in 17 unique patients, across multiple tumor types including non-small cell lung (n=7), breast (n=2), colorectal (n=3), esophageal (n=2), ovarian (n=1), pancreatic (n=1), and unknown primary (n=1) carcinomas, with a cumulative incidence of 0.38%.

Source: Journal of Molecular Diagnostics - May 8, 2023 Category: Pathology Authors: Eric Severson, B.R. Achyut, Mary Nesline, Sarabjot Pabla, Rebecca A. Previs, Geoffrey Kannan, Anjen Chenn, Shengle Zhang, Roger Klein, Jeffrey Conroy, Mark Sausen, Pratheesh Sathyan, Kamal S. Saini, Aradhana Ghosh, Taylor J. Jensen, Prasanth Reddy, Shakti Tags: Regular Article Source Type: research