Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells

Discussion
Jo-1 antibodies from Jo-1 antibody myositis show complement-dependent cellular cytotoxicity in muscle endothelial cells. IgGs from patients with Jo-1, SRP, and DM increase the TREM-1 expression in endothelial cells and muscles.

Source: Neurology Neuroimmunology and Neuroinflammation - May 5, 2023 Category: Neurology Authors: Honda, M., Shimizu, F., Sato, R., Mizukami, Y., Watanabe, K., Takeshita, Y., Maeda, T., Koga, M., Kanda, T. Tags: All Neuromuscular Disease, Muscle disease Research Article Source Type: research