A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancer

Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histon...

Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt and Nilofer S. Azad Tags: Research Source Type: research