Molecules, Vol. 28, Pages 3809: Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro
Molecules, Vol. 28, Pages 3809: Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro
Molecules doi: 10.3390/molecules28093809
Authors:
Lorena R. Sousa
Ana Gabriela S. Oliveira
Antônio Arantes
João Gabriel M. Junqueira
Gerso P. Alexandre
Vanessa G. P. Severino
Rui Manuel Reis
Bonglee Kim
Rosy I. M. A. Ribeiro
Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds. Accordingly, this study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart., enriched with acetogenins, against GBM cell lines. All four fractions were selectively cytotoxic to GBM cells when compared to TMZ. Moreover, A. coriacea fractions delayed cell migration; reduced cytoplasmic projections, the metalloproteinase 2 (MMP-2) activity; and induced morphological changes characteristic of necroptosis, possibly correlated with the increase in receptor-interacting protein kinase 1 and 3 (RIP-1 and RIP-3), apoptosis-inducing factor (AIF), and the non-activation of cleaved caspase 8. The present findings reinforce that fractions of A. coriacea Mart. sho...
Source: Molecules - Category: Chemistry Authors: Lorena R. Sousa Ana Gabriela S. Oliveira Ant ônio Arantes Jo ão Gabriel M. Junqueira Gerso P. Alexandre Vanessa G. P. Severino Rui Manuel Reis Bonglee Kim Rosy I. M. A. Ribeiro Tags: Article Source Type: research
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