A feasibility study of combined treatment using aerobic exercise and duloxetine in adults with symptomatic knee osteoarthritis and comorbid depression

Purpose: Depression is common in patients with knee OA, and clinical guidelines do not advise treating both conditions simultaneously. However, recent research recommends combining interventions that address symptoms of both conditions to maximize efficacy. Exercise improves pain, disability, and mood, but chronic pain and depression are barriers to physical activity in this population. Duloxetine is indicated to treat neuropathic pain and depression among knee OA patients and could serve as a therapeutic complement to exercise.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research