Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation

In this study, we demonstrate that P2X7 plays essential roles in AAA development via modulating macrophage pyroptosis and inflammation. P2X7 is highly expressed in human AAA specimen, as well as in experimental murine AAA lesions (both CaCl2- and Angiotensin II-induced AAA models), and it mainly confines in macrophages.

Source: Translational Research - March 24, 2023 Category: Research Authors: Likun Sun, Xin Li, Zhongchen Luo, Maohua Li, Hongyu Liu, Zhaowei Zhu, Junwei Wang, Peng Lu, Lunchang Wang, Chenzi Yang, Tun Wang, Hao He, Ming Li, Chang Shu, Jiehua Li Source Type: research