Downregulating vaccinia-related kinase 1 by luteolin suppresses ovarian cancer cell proliferation by activating the p53 signaling pathway

CONCLUSIONS: Luteolin demonstrated considerable anticancer effect on HGSOC cells, reduced VRK1 expression, and activated the p53 signaling pathway, thereby inducing apoptosis and cell cycle arrest in G2/M and inhibiting cell proliferation. Furthermore, luteolin exhibited a synergistic effect with cisplatin both in vivo and in vitro. Thus, luteolin can be considered a promising cotreatment option for HGSOC.PMID:37075494 | DOI:10.1016/j.ygyno.2023.04.003

Source: Gynecologic Oncology - April 17, 2023 Category: Cancer & Oncology Authors: Xuboya Chang Satoshi Tamauchi Kosuke Yoshida Masato Yoshihara Akira Yokoi Yusuke Shimizu Yoshiki Ikeda Nobuhisa Yoshikawa Tohru Kiyono Yusuke Yamamoto Hiroaki Kajiyama Source Type: research